Pancreatin is a digestive enzyme that is an extract of the contents of the pancreas. Its constituent pancreatic enzymes - amylase, lipase and protease - are involved in the digestion of carbohydrates, fats and proteins. It is used for diseases of the gastrointestinal tract and in cases of nutritional error. Pancreatin compensates for the lack of activity of its own enzymes, helps to improve the digestion process.
Enzyme preparation from the pancreas of pigs and cattle. Amorphous fine grayish or yellowish powder with a characteristic odor. Slightly soluble in water.
In the acidic environment of the stomach, pancreatin quickly loses its activity, therefore it is usually released in an enteric coating. It is activated in the intestine at pH = 5.5. The average dose for adults is 150 thousand units / day.
Preparations containing pancreatic enzymes can be classified into:
By composition. Both pure pancreatin and those containing additional substances can be used. This parameter determines the indications and contraindications (additional components have their own contraindications):
pancreatin and choleretic agent;
pancreatin, bile components, hemicellulase;
pancreatin and rice fungus extract;
By resistance to gastric hydrochloric acid. Determines the effectiveness of the drug (in the acidic environment of the stomach, pancreatin loses its activity).
The particle size of the drug. Affects the effectiveness, physiology of the drug (particle diameter less than 2 mm provides a synchronous flow of the drug with chyme into the duodenum).
microgranular forms (produced in the form of gelatin capsules containing acid-resistant microspheres or microtablets with a diameter of less than 2 mm).
Digestive enzyme agent, replenishes the deficiency of pancreatic enzymes, has proteolytic, amylolytic and lipolytic effects. The pancreatic enzymes included in the composition (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins to amino acids, fats to glycerol and fatty acids, starch to dextrins and monosaccharides, improves the functional state of the gastrointestinal tract, and normalizes digestion processes.
Trypsin suppresses the stimulated secretion of the pancreas, providing an analgesic effect.
Pancreatic enzymes are released from the dosage form in the alkaline medium of the small intestine, as they are protected from the action of gastric juice by the membrane.
The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
Lack of exocrine pancreatic function (chronic pancreatitis, cystic fibrosis). Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder, conditions after resection or irradiation of these organs, accompanied by impaired digestion of food, flatulence, diarrhea (in the composition of Pancreatin 8000 table. No. fifties combination therapy). To improve the digestion of food in persons with normal gastrointestinal tract function in case of inaccuracies in nutrition, as well as in violation of chewing function. Preparation for X-ray and ultrasound examination of the abdominal organs.